5-Bromopyrimidine
- CAS NO.：4595-59-9
- Empirical Formula: C4H3BrN2
- Molecular Weight: 158.98
- MDL number: MFCD00006117
- EINECS: 224-992-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:22
What is 5-Bromopyrimidine?
Chemical properties
yellow solid crystalline, insoluble in water, soluble in organic solvents such as benzene and toluene.
The Uses of 5-Bromopyrimidine
5-Bromopyrimidine was used in the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction, (5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol.
The Uses of 5-Bromopyrimidine
5-Bromopyrimidine was used in the synthesis of:
N-heteroaryl substituted 9-arylcarbazolyl derivatives via palladium-catalyzed aerobic and ligand-free Suzuki reaction
(5-(phenylethynyl)pyrimidine) via microwave assisted organic synthesis (MAOS) Sonogashira protocol
Intermediate for the synthesis of plant growth regulator flurprimidol
What are the applications of Application
5-Bromopyrimidine is a compound useful in organic synthesis.
Preparation
5-Bromopyrimidine is prepared by reacting dibromodifuranone with formamide in the presence of B2O2 catalyst at 180-185°C to obtain the product.
General Description
Rapid nucleophilic displacement reactions of 5-bromopyrimidine with nucleophiles under microwave irradiation has been studied. 5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine.
Properties of 5-Bromopyrimidine
| Melting point: | 67-73 °C (lit.) |
| Boiling point: | 168°C(lit.) |
| Density | 1.6448 (rough estimate) |
| refractive index | 1.5260 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in chloroform. |
| pka | 1.40±0.10(Predicted) |
| form | Crystalline Powder or Chunks |
| color | Yellow to beige-brown |
| BRN | 107326 |
| CAS DataBase Reference | 4595-59-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyrimidine, 5-bromo-(4595-59-9) |
| EPA Substance Registry System | Pyrimidine, 5-bromo- (4595-59-9) |
Safety information for 5-Bromopyrimidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Bromopyrimidine
5-Bromopyrimidine manufacturer
JSK Chemicals
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