4ALPHA-PHORBOL 12,13-DIDECANOATE
Synonym(s):4αPDD;4αPDD, PKC Activator I, Negative Control;4α-Phorbol 12-13-dicaprinate;4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem
- CAS NO.：27536-56-7
- Empirical Formula: C40H64O8
- Molecular Weight: 672.93
- MDL number: MFCD00036737
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is 4ALPHA-PHORBOL 12,13-DIDECANOATE?
The Uses of 4ALPHA-PHORBOL 12,13-DIDECANOATE
4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:
- to study its effects on Madin-Darby canine kidney (MDCK) cells
- to study its effects on Ca2+ influx in mice fallopian tubal cells
- to study its effects on hind paw swelling in mice
What are the applications of Application
4α-Phorbol 12,13-didecanoate is an activator of TRPV4
Definition
ChEBI: 4alpha-phorbol 12,13-didecanoate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding decanoate esters. A Trpv4-specific ligand. It has a role as a TRPV4 agonist. It is a phorbol ester, a decanoate ester, a tertiary alpha-hydroxy ketone, a diester and a primary allylic alcohol.
Biochem/physiol Actions
4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.
Properties of 4ALPHA-PHORBOL 12,13-DIDECANOATE
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | solid |
| color | white |
| BRN | 2514324 |
Safety information for 4ALPHA-PHORBOL 12,13-DIDECANOATE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H317:Sensitisation, Skin H334:Sensitisation, respiratory H351:Carcinogenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4ALPHA-PHORBOL 12,13-DIDECANOATE
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