4-Tolylboronic acid

Synonym(s):4-Tolylboronic acid;4-Methylbenzeneboronic acid;4-Methylphenylboronic acid;4-Tolueneboronic acid;p-Methylbenzeneboronic acid

white to light yellow crystal powder

suzuki reaction

4-Methylbenzeneboronic acid, is a commonly used chemical in Suzuki coupling reactions. It is also used as an intermediate in pharmaceutical industry

Reagent used for

Palladium (Pd)-catalyzed direct arylation
Direct Palladium(II)-Catalyzed Synthesis
Palladium-catalyzed arylation by Suzuki-Miyaura cross-coupling in water
Cyclopalladation
Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence
Ruthenium catalyzed direct arylation
Rhodium-catalyzed asymmetric conjugate addition
Ligand-free copper-catalyzed cross-coupling reactions
Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions
Ligand-free Suzuki, Sonogashira, and Heck cross-coupling reactions

Reagent used in Preparation of

Catalysts for Suzuki-Miyaura cross-coupling of aryl bromides
Recyclable Palladium nanoparticle catalysts immobilized by click ionic copolymers as for Suzuki-Miyaura cross-coupling reactions in water

Melting point:	256-263 °C(lit.)
Boiling point:	275.2±33.0 °C(Predicted)
Density	1.10±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Crystalline Powder
pka	8.84±0.10(Predicted)
color	Off-white
Water Solubility	It is soluble in water.
BRN	2935970
CAS DataBase Reference	5720-05-8(CAS DataBase Reference)
NIST Chemistry Reference	P-methylbenzeneboronic acid(5720-05-8)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.