4-Phenylamino-6,7-dimethoxyquinazoline
- CAS NO.：21561-09-1
- Empirical Formula: C16H15N3O2
- Molecular Weight: 281.31
- MDL number: MFCD01815294
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:52:00
What is 4-Phenylamino-6,7-dimethoxyquinazoline?
Description
WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 μM. However, it is inactive at JAK3 (IC50 = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.
The Uses of 4-Phenylamino-6,7-dimethoxyquinazoline
4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3).
Properties of 4-Phenylamino-6,7-dimethoxyquinazoline
| Boiling point: | 441.2±40.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml |
| form | A crystalline solid |
| pka | 6.19±0.70(Predicted) |
| color | White to off-white |
Safety information for 4-Phenylamino-6,7-dimethoxyquinazoline
Computed Descriptors for 4-Phenylamino-6,7-dimethoxyquinazoline
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![Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-](https://img.chemicalbook.in/CAS/20150408/GIF/211555-08-7.gif)
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