4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
Synonym(s):4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid;8BCA
- CAS NO.：59662-49-6
- Empirical Formula: C21H26O2
- Molecular Weight: 310.43
- MDL number: MFCD00157040
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:24:32
What is 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID?
The Uses of 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).
What are the applications of Application
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist
Definition
ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.
Biological Activity
Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Biochem/physiol Actions
AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.
Properties of 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
| Melting point: | 148-152 °C(Solv: dichloromethane (75-09-2)) |
| Boiling point: | 462.0±34.0 °C(Predicted) |
| Density | 1.037±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: >7mg/mL |
| form | solid |
| pka | 4.23±0.10(Predicted) |
| color | White to off-white |
Safety information for 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
Computed Descriptors for 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
New Products
2-Bromo-4-hydroxypyridine Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1-aminocyclobutanecarbonitrile hydrochloride AMINO-O-TOLYL-ACETIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 3-Oxocyclobutanecarboxylic acid METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 2-(2-Bromophenyl)ethanol Boc-D-Glu(OMe)-OMe 2,5 Dibromopyridine Ethyl 4-hydroxy-3-oxobutanoate Dimethyl (2S)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
You may like
-
4''-OCTYL-4-BIPHENYLCARBOXYLIC ACID CAS 59662-49-6View Details
59662-49-6 -
254762-66-8 AMINO(2-BROMOPHENYL)ACETIC ACID 98+View Details
254762-66-8 -
254762-66-8 AMINO(2-BROMOPHENYL)ACETIC ACID 98+View Details
254762-66-8 -
23716-23-1 98+View Details
23716-23-1 -
6-BROMOTETRAZOLO[1,5-A]PYRIDINE 98+View Details
5799-75-7 -
254762-66-8 AMINO(2-BROMOPHENYL)ACETIC ACID 98+View Details
254762-66-8 -
23716-23-1 98+View Details
23716-23-1 -
6-BROMOTETRAZOLO[1,5-A]PYRIDINE 98+View Details
5799-75-7