4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
Synonym(s):4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid;8BCA
- CAS NO.：59662-49-6
- Empirical Formula: C21H26O2
- Molecular Weight: 310.43
- MDL number: MFCD00157040
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:24:32
What is 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID?
The Uses of 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).
What are the applications of Application
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist
Definition
ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.
Biological Activity
Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Biochem/physiol Actions
AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.
Properties of 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
| Melting point: | 148-152 °C(Solv: dichloromethane (75-09-2)) |
| Boiling point: | 462.0±34.0 °C(Predicted) |
| Density | 1.037±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: >7mg/mL |
| form | solid |
| pka | 4.23±0.10(Predicted) |
| color | White to off-white |
Safety information for 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
Computed Descriptors for 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
New Products
2-Amino-5-bromo- benzoic acid Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one BOC Piperazine N-Methyl-2-amino-2-methylpropionamide 4-(FMOC-AMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride 3-Oxocyclobutanecarboxylic acid AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 4-Amino-2-chloro-6,7-dimethoxyquinazoline 2,3-Dimethoxypyridine 2,6-bis(bromomethyl)pyridine tert-Butyl 4-mercaptopiperidine-1-carboxylate 4'-(Methylmercapto)-acetophrnonone 1-Benzhydrylazetidin-3-ol-Hcl 1-(3-Chlorophenyl)piperazine hydrochloride Enzyme Breaker for Coal Bed Methane Slickwaterr Gas Well Guar Gum Enzyme Breaker Enzyme Breaker for Conventional Slickwater Fracturing Conventional Fracturing Guar Gum Enzyme Breaker Coalbed Methane Guar Gum Enzyme BreakerRelated products of tetrahydrofuran
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