4'-Methylpropiophenone

Chemical properties

clear light yellow liquid

The Uses of 4'-Methylpropiophenone

4′-Methylpropiophenone is a chemical reagent used in electrocarboxylation reactions. It has been reported to be used in the synthesis of pharmaceutical compounds such as tolperisone and other muscle relaxants.

Definition

ChEBI: 4-methylpropiophenone is an aromatic ketone that is propiophenone bearing a methyl group at C-4. It derives from a propiophenone.

Synthesis

4'-Methylpropiophenone can be synthesized through various methods. One common approach involves the reaction of propiophenone with methylmagnesium bromide or methyl lithium in the presence of a catalyst. Another method utilizes Friedel-Crafts acylation, where propiophenone is acylated with methyl chloride or methyl bromide using a Lewis acid catalyst. These methods allow for the controlled introduction of the methyl group onto the phenyl ring.