4-Methoxycinnamic acid
Synonym(s):trans-3-(4-Methoxyphenyl)acrylic acid
- CAS NO.：830-09-1
- Empirical Formula: C10H10O3
- Molecular Weight: 178.18
- MDL number: MFCD00004398
- EINECS: 212-594-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:52:44
What is 4-Methoxycinnamic acid?
Chemical properties
white fine crystalline powde
The Uses of 4-Methoxycinnamic acid
4-Methoxycinnamic acid(p-MCA) exerted antihyperglycemic/hypoglycemic effect by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.
The Uses of 4-Methoxycinnamic acid
It exerts anti-hyperglycemic/ hypoglycemic effect by stimulating insulin secretion from pancreas. It could be developed into a new potential therapeutic agent used in type 2 diabetic patients.
Definition
ChEBI: A methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring.
Synthesis Reference(s)
Journal of the American Chemical Society, 79, p. 3452, 1957 DOI: 10.1021/ja01570a037
Tetrahedron Letters, 31, p. 5913, 1990 DOI: 10.1016/S0040-4039(00)97992-9
Purification Methods
Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]
Properties of 4-Methoxycinnamic acid
| Melting point: | 173.5 °C(lit.) |
| Boiling point: | 250.41°C (rough estimate) |
| Density | 1.1479 (rough estimate) |
| refractive index | 1.5088 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in dimethyl sulfoxide and methanol. |
| pka | pK1:4.539 (25°C) |
| form | Fine Crystalline Powder |
| color | White |
| InChI | InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12) |
| CAS DataBase Reference | 830-09-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Propenoic acid, 3-(4-methoxyphenyl)-(830-09-1) |
| EPA Substance Registry System | 2-Propenoic acid, 3-(4-methoxyphenyl)- (830-09-1) |
Safety information for 4-Methoxycinnamic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Methoxycinnamic acid
| InChIKey | AFDXODALSZRGIH-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C=CC1=CC=C(OC)C=C1 |
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