4'-HYDROXYCHALCONE
- CAS NO.：2657-25-2
- Empirical Formula: C15H12O2
- Molecular Weight: 224.25
- MDL number: MFCD00016484
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-03 11:24:09
What is 4'-HYDROXYCHALCONE?
Description
4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.
Chemical properties
yellow-cream powder
The Uses of 4'-HYDROXYCHALCONE
antineoplastic,
The Uses of 4'-HYDROXYCHALCONE
4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).
Definition
ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.
Properties of 4'-HYDROXYCHALCONE
| Melting point: | 174-178 °C |
| Boiling point: | 419.6±45.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml |
| pka | 7.72±0.15(Predicted) |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| BRN | 2049150 |
| CAS DataBase Reference | 2657-25-2(CAS DataBase Reference) |
Safety information for 4'-HYDROXYCHALCONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4'-HYDROXYCHALCONE
| InChIKey | UAHGNXFYLAJDIN-IZZDOVSWSA-N |
New Products
Pentadecanoic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 2-Bromo-5-Iodopyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Tetrahydropyranyl-4-acetic acid Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside 5-fluoro-1,3-benzodioxole 2-Bromo-6-fluoroaniline 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-oneRelated products of tetrahydrofuran
You may like
-
2657-25-2 4'-Hydroxy chalcone 98%View Details
2657-25-2 -
2657-25-2 98%View Details
2657-25-2 -
4'-Hydroxychalcone CAS 2657-25-2View Details
2657-25-2 -
4′-hydroxychalcone CASView Details
-
2-Bromo-4-nitropyridine-N-oxide 52092-43-0 98%View Details
52092-43-0 -
4, 4'-Ditolylamine (or) 4,4-Dimethyl Diphenylamine 620-93-9 98%View Details
620-93-9 -
2-Bromo-5-Chloropyridine 98%View Details
40473-01-6 -
Eperisone Hydrochloride APIView Details
56839-43-1