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HomeProduct name list4'-HYDROXYCHALCONE

4'-HYDROXYCHALCONE

4'-HYDROXYCHALCONE Structural

What is 4'-HYDROXYCHALCONE?

Description

4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.

Chemical properties

yellow-cream powder

The Uses of 4'-HYDROXYCHALCONE

antineoplastic,

The Uses of 4'-HYDROXYCHALCONE

4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.

Properties of 4'-HYDROXYCHALCONE

Melting point: 174-178 °C
Boiling point: 419.6±45.0 °C(Predicted)
Density  1.191±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,Room Temperature
solubility  DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
pka 7.72±0.15(Predicted)
form  powder to crystal
color  Light orange to Yellow to Green
BRN  2049150
CAS DataBase Reference 2657-25-2(CAS DataBase Reference)

Safety information for 4'-HYDROXYCHALCONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 4'-HYDROXYCHALCONE

InChIKey UAHGNXFYLAJDIN-IZZDOVSWSA-N

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