4-Fluorobenzotrifluoride

Synonym(s):α,α,α,4-Tetrafluorotoluene

CAS NO.：402-44-8
Empirical Formula: C7H4F4
Molecular Weight: 164.1
MDL number: MFCD00000399
EINECS: 206-944-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 4-Fluorobenzotrifluoride?

Chemical properties

Clear colourless to light yellow liquid

The Uses of 4-Fluorobenzotrifluoride

4-Fluorobenzotrifluoride was used in the synthesis of 2,2?-bis(trifluoromethylphenoxy)biphenyl via nucleophilic aromatic substitution reaction with 2,2?-biphenol, (S)-fluoxetine, potent inhibitor of neuronal serotonin-uptake and 1-aryloxy-2-substituted aminomethyltetrahydronaphthalene derivatives.

Synthesis Reference(s)

Tetrahedron, 49, p. 8129, 1993 DOI: 10.1016/S0040-4020(01)88032-7

Properties of 4-Fluorobenzotrifluoride

Melting point:	−42-−41.7 °C(lit.)
Boiling point:	102-105 °C(lit.)
Density	1.293 g/mL at 25 °C(lit.)
refractive index	n20/D 1.401(lit.)
Flash point:	51 °F
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
color	Clear colorless
Specific Gravity	1.2930
Water Solubility	Slightly soluble in water.
BRN	1909390
CAS DataBase Reference	402-44-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-fluoro-4-(trifluoromethyl)-(402-44-8)
EPA Substance Registry System	4-Fluorobenzotrifluoride (402-44-8)

Safety information for 4-Fluorobenzotrifluoride

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.