4-Fluorobenzotrifluoride
Synonym(s):α,α,α,4-Tetrafluorotoluene
- CAS NO.：402-44-8
- Empirical Formula: C7H4F4
- Molecular Weight: 164.1
- MDL number: MFCD00000399
- EINECS: 206-944-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:54
What is 4-Fluorobenzotrifluoride?
Chemical properties
Clear colourless to light yellow liquid
The Uses of 4-Fluorobenzotrifluoride
4-Fluorobenzotrifluoride was used in the synthesis of 2,2?-bis(trifluoromethylphenoxy)biphenyl via nucleophilic aromatic substitution reaction with 2,2?-biphenol, (S)-fluoxetine, potent inhibitor of neuronal serotonin-uptake and 1-aryloxy-2-substituted aminomethyltetrahydronaphthalene derivatives.
Synthesis Reference(s)
Tetrahedron, 49, p. 8129, 1993 DOI: 10.1016/S0040-4020(01)88032-7
Properties of 4-Fluorobenzotrifluoride
| Melting point: | −42-−41.7 °C(lit.) |
| Boiling point: | 102-105 °C(lit.) |
| Density | 1.293 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 51 °F |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| color | Clear colorless |
| Specific Gravity | 1.2930 |
| Water Solubility | Slightly soluble in water. |
| BRN | 1909390 |
| CAS DataBase Reference | 402-44-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-fluoro-4-(trifluoromethyl)-(402-44-8) |
| EPA Substance Registry System | 4-Fluorobenzotrifluoride (402-44-8) |
Safety information for 4-Fluorobenzotrifluoride
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Fluorobenzotrifluoride
4-Fluorobenzotrifluoride manufacturer
BTC Pharmaceuticals Technology India
Andhra Pradesh
product: 4-Fluorobenzotrifluoride CAS NO:402-44-8
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