4-Dodecanolide

Synonym(s):(±)-γ-Octyl-γ-butyrolactone;(±)-4-Dodecanolide;(±)-Dihydro-5-octyl-2(3H)-furanone

CAS NO.：2305-05-7
Empirical Formula: C12H22O2
Molecular Weight: 198.3
MDL number: MFCD00036499
EINECS: 218-971-6
SAFETY DATA SHEET (SDS)
Update Date: 2026-10-27 18:05:23

What is 4-Dodecanolide ?

Chemical properties

γ-Dodecalactone has a fatty, peachy, somewhat musky odor and buttery, peach-like flavor

Occurrence

Reported found in apricot, cooked pork, milk products, peach, bilberry, guava fruit, papaya, pineapple, fresh blackberry, strawberry, celery leaves and stalks, celery root, blue cheeses, cheddar cheese, Swiss cheese, meats, beer, rum, mushrooms, plum brandy, quince, chervil, naranjilla fruit and other natural sources

The Uses of 4-Dodecanolide

4-Dodecanolide was one of the organic compounds from meat charbroiling operations studied.

Preparation

From 1-dodecen-12-oic acid with H2SO4 at 90°C; from 4-hydroxydodecanoic acid by lactonization; also from methylacrylate and octanol

Definition

ChEBI: Xi-Dihydro-5-octyl-2(3H)-furanone is a gamma-lactone.

Aroma threshold values

Detection: 7 ppb; aroma characteristics at 1.0%; sweet, creamy, fruity peach and apricot, lactonic, with dairy waxy and fatty nuances.

Taste threshold values

Taste characteristics at 1 to 10 ppm: sweet, fruity peach, milky fatty and waxy with a pulpy fruity mouthfeel.

Synthesis Reference(s)

Journal of the American Chemical Society, 108, p. 3745, 1986 DOI: 10.1021/ja00273a032
Organic Syntheses, Coll. Vol. 7, p. 400, 1990

Safety Profile

A skin irritant. When heated todecomposition it emits acrid smoke and irritating vapors

Properties of 4-Dodecanolide

Melting point:	17-18 °C(lit.)
Boiling point:	130-132 °C1.5 mm Hg(lit.)
Density	0.936 g/mL at 25 °C(lit.)
vapor pressure	7.3hPa at 20℃
refractive index	n20/D 1.452(lit.)
FEMA	2400 \| GAMMA-DODECALACTONE
Flash point:	>230 °F
storage temp.	Refrigerator, under inert atmosphere
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Oil
color	Colourless
Specific Gravity	0.94
Odor	at 100.00 %. fatty peach sweet metallic fruity
Water Solubility	60mg/L at 20℃
JECFA Number	235
BRN	126680
CAS DataBase Reference	2305-05-7(CAS DataBase Reference)
NIST Chemistry Reference	«GAMMA» dodecalactone(2305-05-7)
EPA Substance Registry System	2(3H)-Furanone, dihydro-5-octyl- (2305-05-7)

Safety information for 4-Dodecanolide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.