4-CYANOIMIDAZOLE
- CAS NO.：108257-41-6
- Empirical Formula: C5H5N3
- Molecular Weight: 107.11
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 09:54:49
What is 4-CYANOIMIDAZOLE?
Preparation
A mixture of ethyl 4-imidazolecarboxylate (33 g) and ammonium hydroxide (250 mL) was heated to 100 C° in a sealed glass vessel for 1–7 days. The mixture was then cooled and the solid 4-imidazolecarboxamide 1443 was recovered by filtration in near quantitative yield and air dried. Dehydration was carried out by heating a solution of 4-imidazolecarboxamide 1443 (5 g) in PhPOCl2 (25 mL) at 80 C° for 12 h. The cooled reaction mixture was then poured over ice (200 mL) and adjusted to pH 11 with 50% aqueous sodium hydroxide. The 4-cyanoimidazole 1444 was isolated by extraction with ethyl acetate and concentration of the extracts in vacuo.
Properties of 4-CYANOIMIDAZOLE
| Boiling point: | 381℃ |
| Density | 1.21 |
| Flash point: | 129℃ |
| storage temp. | 2-8°C |
| pka | 9.60±0.10(Predicted) |
Safety information for 4-CYANOIMIDAZOLE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-CYANOIMIDAZOLE
4-CYANOIMIDAZOLE manufacturer
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