4'-CHLORODIAZEPAM
Synonym(s):4ʹ-chlorodiazepam, TSPO Activator I, Mitochondrial Translocator Protein Activator I, Ro54864;7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one;Ro 5-4864;Ro5-4864;TSPO Agonist, Ro5-4864 - CAS 14439-61-3 - Calbiochem
- CAS NO.：14439-61-3
- Empirical Formula: C16H12Cl2N2O
- Molecular Weight: 319.19
- MDL number: MFCD00043406
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:08
What is 4'-CHLORODIAZEPAM?
The Uses of 4'-CHLORODIAZEPAM
4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines.
Biochem/physiol Actions
4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.
Properties of 4'-CHLORODIAZEPAM
| Melting point: | 160-163 °C |
| Boiling point: | 517.1±50.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | ethanol: 17 mg/mL |
| form | Off-white powder |
| pka | 3.08±0.10(Predicted) |
| color | White to light yellow |
| BRN | 685202 |
Safety information for 4'-CHLORODIAZEPAM
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 4'-CHLORODIAZEPAM
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![1-METHYL-5-PHENYL-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE](https://img.chemicalbook.in/CAS/GIF/3034-65-9.gif)
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