4-Chlorobenzyl bromide
- CAS NO.：622-95-7
- Empirical Formula: C7H6BrCl
- Molecular Weight: 205.48
- MDL number: MFCD00040714
- EINECS: 210-760-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:22:46
What is 4-Chlorobenzyl bromide?
Chemical properties
White crystalline low melting solid
The Uses of 4-Chlorobenzyl bromide
4-Chlorobenzyl bromide is used as pharmaceutical intermediate.
The Uses of 4-Chlorobenzyl bromide
4-Chlorobenzyl bromide may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride
General Description
4-Chlorobenzyl bromide undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid. It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Properties of 4-Chlorobenzyl bromide
| Melting point: | 48-52 °C (lit.) |
| Boiling point: | 107-108°C 8mm |
| Density | 1.570±0.06 g/cm3(Predicted) |
| Flash point: | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform, Dichloromethane (Slightly) |
| form | Crystalline Low Melting Solid |
| color | White |
| Water Solubility | Insoluble in water. |
| Sensitive | Lachrymatory |
| BRN | 606497 |
| CAS DataBase Reference | 622-95-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Chlorobenzyl bromide(622-95-7) |
Safety information for 4-Chlorobenzyl bromide
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Chlorobenzyl bromide
| InChIKey | KQNBRMUBPRGXSL-UHFFFAOYSA-N |
4-Chlorobenzyl bromide manufacturer
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