4'-CHLOROACETANILIDE
Synonym(s):4-Chloroacetanilide;Acetic acid 4-chloroanilide;N-(4-chlorophenyl)-acetamide;N-(4-Chlorophenyl)acetamide;4′-Chloroacetanilide
- CAS NO.：539-03-7
- Empirical Formula: C8H8ClNO
- Molecular Weight: 169.61
- MDL number: MFCD00000612
- EINECS: 208-707-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:45:43
What is 4'-CHLOROACETANILIDE?
Chemical properties
white or greyish-beige crystalline powder
The Uses of 4'-CHLOROACETANILIDE
4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.
Definition
ChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.
Synthesis Reference(s)
Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4
General Description
4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.
Purification Methods
Crystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]
Properties of 4'-CHLOROACETANILIDE
| Melting point: | 176-178 °C(lit.) |
| Boiling point: | 333 °C |
| Density | 1,385 g/cm3 |
| refractive index | 1.5670 (estimate) |
| Flash point: | 333°C |
| storage temp. | 2-8°C |
| solubility | dioxane: 50 mg/mL hot, clear |
| form | Crystalline Powder |
| pka | 14.25±0.70(Predicted) |
| color | White or grayish-beige |
| Water Solubility | Insoluble in water. |
| Merck | 14,2111 |
| BRN | 509638 |
| CAS DataBase Reference | 539-03-7(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Chloroacetanilide (539-03-7) |
Safety information for 4'-CHLOROACETANILIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4'-CHLOROACETANILIDE
4'-CHLOROACETANILIDE manufacturer
Suvchem
Maharashtra
Phone:91-9821198699
Whatsapp: 91-9821198699
product: N-(4-chlorophenyl)-acetamide
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: N-(4-chlorophenyl)-acetamide
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