4-Chloro-4'-hydroxybenzophenone

CAS NO.：42019-78-3
Empirical Formula: C13H9ClO2
Molecular Weight: 232.66
MDL number: MFCD00002357
EINECS: 255-627-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 17:10:26

What is 4-Chloro-4'-hydroxybenzophenone?

Chemical properties

light grey to beige-brown powder

The Uses of 4-Chloro-4'-hydroxybenzophenone

4-Chloro-4’-hydroxybenzophenone (Fenofibrate EP Impurity A; Fenofibrate USP Related Compound A) the impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner.

Preparation

Preparation by Fries rearrangement of phenyl p-chloro-benzoate,
? in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%);
? in the presence of trifluoromethanesulfonic acid at 45–55° (94%).

Description

4-Chloro-4'-hydroxybenzophenone is a benzophenone derivative that can be used as a reagent for the synthesis of benzophenone chromogenic groups on cotton fabrics for the determination of antimicrobial and chemical detoxification of cotton fabrics.

Properties of 4-Chloro-4'-hydroxybenzophenone

Melting point:	177-181 °C
Boiling point:	257 °C (13 mmHg)
Density	1.2082 (rough estimate)
refractive index	1.5434 (estimate)
Flash point:	100 °C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	neat
pka	7.68±0.15(Predicted)
color	Pale Beige to Light Brown
BRN	2049956
CAS DataBase Reference	42019-78-3(CAS DataBase Reference)
NIST Chemistry Reference	Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-(42019-78-3)

Safety information for 4-Chloro-4'-hydroxybenzophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.