4-CHLORO-2-NITROPHENOL

CAS NO.：89-64-5
Empirical Formula: C6H4ClNO3
Molecular Weight: 173.55
MDL number: MFCD00007113
EINECS: 201-927-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 04:20:48

What is 4-CHLORO-2-NITROPHENOL?

Chemical properties

yellow powder

The Uses of 4-CHLORO-2-NITROPHENOL

Reduction of 4-Chloro-2-nitrophenol gives 2-amino-4- chlorophenol [95-85-2], and chlorination yields 2,4-dichloro-6-nitrophenol [609-89-2], which is reduced to 2-amino-4,6-dichlorophenol [527-62-8]. These substituted aminophenols are members of a large class of diazo components used for hydroxyazo dyes, which are important for wool and polyamide when converted to their chromium complexes. For the amine derived from the methyl ether of 4-Chloro-2-nitrophenol, 4- chloro-o-anisidine [93-50-5], the preferred route is methoxylation of 2,5-dichloronitrobenzene followed by reduction. 2-amino-4-chlorophenol reacts with phosgene to give 5- chlorobenzoxolinone which nitrates to the 6-nitro compound; the latter undergoes alkaline hydrolysis to 2-amino-4- chloro-5-nitrophenol.

Production Methods

2,5-Dichloronitrobenzene is hydrolyzed with 8 % aqueous sodium hydroxide at 120 – 130 ℃ under pressure.

Properties of 4-CHLORO-2-NITROPHENOL

Melting point:	85-87 °C(lit.)
Boiling point:	242.5±20.0 °C(Predicted)
Density	1.4914 (rough estimate)
refractive index	1.5810 (estimate)
solubility	dioxane: soluble0.5g/5mL, clear, faintly yellow to yellow
pka	pK1: 6.48 (25°C)
form	powder to crystal
color	Light yellow to Yellow to Orange
BRN	2048031
CAS DataBase Reference	89-64-5(CAS DataBase Reference)
EPA Substance Registry System	4-Chloro-2-nitrophenol (89-64-5)

Safety information for 4-CHLORO-2-NITROPHENOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.