4-Chloro-2-methylthiopyrimidine

CAS NO.：49844-90-8
Empirical Formula: C5H5ClN2S
Molecular Weight: 160.62
MDL number: MFCD00006083
EINECS: 256-500-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 4-Chloro-2-methylthiopyrimidine?

Chemical properties

Clear yellow to brown liquid

The Uses of 4-Chloro-2-methylthiopyrimidine

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

The Uses of 4-Chloro-2-methylthiopyrimidine

4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.

Properties of 4-Chloro-2-methylthiopyrimidine

Melting point:	−2 °C(lit.)
Boiling point:	139-140 °C36 mm Hg(lit.)
Density	1.381 g/mL at 25 °C(lit.)
refractive index	n20/D 1.6(lit.)
Flash point:	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	-0.56±0.20(Predicted)
form	liquid
color	Colorless to Red to Green
Water Solubility	Not miscible or difficult to mix in water.
Sensitive	Hygroscopic
BRN	118042
CAS DataBase Reference	49844-90-8(CAS DataBase Reference)

Safety information for 4-Chloro-2-methylthiopyrimidine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.