4-(2-Bromoethynyl)benzoic acid
- CAS NO.：1485684-77-2
- Empirical Formula: C9H5BrO2
- Molecular Weight: 225.04
- Update Date: 2026-05-27 17:33:42
What is 4-(2-Bromoethynyl)benzoic acid?
Synthesis
To a solution of methyl 4,-(bromomethyl) benzoate (67 g, 250 mmol, 10 equiv) in (1100 mL) was added NaOH (44,84 g, 4,0 equiv) and the reaction mixture was stirred at 25°C for 3 hr. The volatiles were removed under reduced pressure and the resulting solution was neutralized with 1 HCl to pH 3-5. 4- (bromomethyl) benzoic acid (INT-1.5) was collected by filtration. The filter cake was washed with water and dried in an oven at 50°C for 5 hr to yield 4- (broMoethynyl)benzoic acid (61g, 96%).
Safety information for 4-(2-Bromoethynyl)benzoic acid
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