4-Aminobenzohydrazide
Synonym(s):Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem
- CAS NO.：5351-17-7
- Empirical Formula: C7H9N3O
- Molecular Weight: 151.17
- MDL number: MFCD00007606
- EINECS: 226-324-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-08 19:11:55
What is 4-Aminobenzohydrazide?
Description
4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.3 μM). It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils with IC50 values of 16 and 2.2 μM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells. It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day.
Chemical properties
White or beige crystals or powder
The Uses of 4-Aminobenzohydrazide
4-Aminobenzoic hydrazide can be used as a reactant to synthesize:
- Acylhydrazone Schiff base ligand by condensation reaction with 2-acetylpyridine.
- Oligomeric transition metal complexes applicable in the fabrication of organic-inorganic hybrid devices with efficient electrical and photoelectrical properties.
- Oxovanadium(IV)-hydrazide complex as a potential radical scavenger.
The Uses of 4-Aminobenzohydrazide
4-Aminobenzhydrazide has an important role in the peroxidation activity of MPO. It is also used in enzyme preparations and in cell cultures.
What are the applications of Application
Myeloperoxidase Inhibitor-I is an irreversible and specific inhibitor of the peroxidation activity of MPO
Properties of 4-Aminobenzohydrazide
| Melting point: | 225-227 °C (lit.) |
| Boiling point: | 273.17°C (rough estimate) |
| Density | 1.2100 (rough estimate) |
| refractive index | 1.5860 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml |
| pka | 13.05±0.10(Predicted) |
| form | Crystals or Powder |
| color | White or beige |
| Water Solubility | Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible). |
| BRN | 639053 |
| CAS DataBase Reference | 5351-17-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-amino-, hydrazide(5351-17-7) |
Safety information for 4-Aminobenzohydrazide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-Aminobenzohydrazide
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