4-Aminobenzamidine dihydrochloride

Synonym(s):p-Aminobenzimidamide dihydrochloride

CAS NO.：2498-50-2
Empirical Formula: C7H11Cl2N3
Molecular Weight: 208.09
MDL number: MFCD00013001
EINECS: 219-692-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-23 18:03:16

4-Aminobenzamidine dihydrochloride Structural

What is 4-Aminobenzamidine dihydrochloride?

Chemical properties

white to yellowish fine crystalline powder

The Uses of 4-Aminobenzamidine dihydrochloride

4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is used as a ligand in affinity chromatography for purification and immobilization of enzymes.

What are the applications of Application

4-Aminobenzamidine dihydrochloride can be used to synthesize:
Orally active fibrinogen receptor antagonists based on benzamidines.
Benzamidine derivatives that are selective and potent serine protease inhibitors.
Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.
Synthesis of a selective inhibitor of PRMT1 (SKLB-639)

Preparation

4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid.

Definition

ChEBI: P-Aminobenzamidine dihydrochloride is an organic molecular entity.

Properties of 4-Aminobenzamidine dihydrochloride

Melting point:	>300 °C(lit.)
storage temp.	2-8°C
solubility	DMSO (Slightly), Water
form	Fine Crystalline Powder
color	White to yellow
Sensitive	Hygroscopic
BRN	3692927
Stability:	Hygroscopic
CAS DataBase Reference	2498-50-2(CAS DataBase Reference)

Safety information for 4-Aminobenzamidine dihydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.