4-amino-2-fluoro-N-methylbenzamide
- CAS NO.：915087-25-1
- Empirical Formula: C8H9FN2O
- Molecular Weight: 168.17
- MDL number: MFCD09909322
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 22:30:02
What is 4-amino-2-fluoro-N-methylbenzamide?
The Uses of 4-amino-2-fluoro-N-methylbenzamide
4-?Amino-?2-?fluoro-?N-?methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors
Description
4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.
Preparation
2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.
Properties of 4-amino-2-fluoro-N-methylbenzamide
| Melting point: | 160 - 163°C |
| Boiling point: | 320℃ |
| Density | 1.234 |
| Flash point: | 147℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.12±0.46(Predicted) |
| color | White to Off-White |
| Stability: | Moisture Sensitive |
| InChI | InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12) |
Safety information for 4-amino-2-fluoro-N-methylbenzamide
Computed Descriptors for 4-amino-2-fluoro-N-methylbenzamide
| InChIKey | XOKAXPQJUODMSH-UHFFFAOYSA-N |
| SMILES | C(NC)(=O)C1=CC=C(N)C=C1F |
4-amino-2-fluoro-N-methylbenzamide manufacturer
Ina pharmaceuticals Pvt Ltd
Vidgas Science & Technologies Pvt Ltd
SYNTHENTA PVT LTD
New Products
1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one Cis-Tosylate Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D BENZENE-D6 TOLUENE-D3 2-Hydroxybutanenitrile 1-Benzylindolin-2-one Ethyl 2-bromo-3-oxobutanoate 4-(3-chloropropyl)morpholine 1-Benzylindoline-2,3-dione 3-Oxocyclobutanecarboxylic acid 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
![4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-](https://img.chemicalbook.in/CAS/20210111/GIF/1289942-55-7.gif)
![[2H6]-Enzalutamide](https://img.chemicalbook.in/CAS/20211123/GIF/1443331-94-9.gif)
You may like
-
915087-25-1 4-Amino-2-Fluoro-N-Methylbenzamide 99%View Details
915087-25-1 -
N-Methyl-2-fluoro-4- aminobenzamide 915087-25-1 99%View Details
915087-25-1 -
915087-25-1 98%View Details
915087-25-1 -
4-Amino-2-fluoro-N-methyl-benzamide 98%View Details
915087-25-1 -
915087-25-1 99%View Details
915087-25-1 -
915087-25-1 ABOVE 99%View Details
915087-25-1 -
4-Amino-2-fluoro-N-methylbenzamide 915087-25-1 99%View Details
915087-25-1 -
4-Amino-2-fluoro-N-methylbenzamide 97-99 %View Details
915087-25-1