4-Amidinophenylmethanesulfonyl fluoride hydrochloride
Synonym(s):p-Amidinophenylmethylsulfonylfluoride, HCl;p-APMSF;p-APMSF, Hydrochloride - CAS 74938-88-8 - Calbiochem;4-Amidinobenzylsulfonyl fluoride hydrochloride
- CAS NO.：74938-88-8
- Empirical Formula: C8H10ClFN2O2S
- Molecular Weight: 252.69
- MDL number: MFCD00036898
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:05:18
What is 4-Amidinophenylmethanesulfonyl fluoride hydrochloride?
Description
p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively. It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase.
What are the applications of Application
p-APMSF, Hydrochloride is an irreversible and specific protease inhibitor
Biochem/physiol Actions
Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.
Properties of 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
| Melting point: | ~205 °C (dec.) |
| storage temp. | -20°C |
| solubility | H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems. |
| form | White solid |
| BRN | 9083148 |
| CAS DataBase Reference | 74938-88-8(CAS DataBase Reference) |
Safety information for 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
| InChIKey | KHLLRHIUKOJXLL-UHFFFAOYSA-N |
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