(3S,5R)-Rosuvastatin
- CAS NO.：1242184-42-4
- Empirical Formula: C22H28FN3O6S
- Molecular Weight: 481.54
- MDL number: MFCD28579810
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is (3S,5R)-Rosuvastatin?
Description
Rosuvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
The Uses of (3S,5R)-Rosuvastatin
(3S,5R,6E)-Rosuvastatin is an isomer of Rosuvastatin(R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor.
Biological Activity
(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
Properties of (3S,5R)-Rosuvastatin
| Boiling point: | 745.6±70.0 °C(Predicted) |
| Density | 1.368±0.06 g/cm3(Predicted) |
| solubility | soluble in Methanol, Water |
| pka | 4.25±0.10(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Stability: | Hygroscopic |
Safety information for (3S,5R)-Rosuvastatin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (3S,5R)-Rosuvastatin
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