3,5-Dibromo-1H-pyrazole

Chemical properties

3,5-Dibromo-1H-pyrazole is a chemical compound that belongs to the group of c1-c6 alkoxy. It has been shown to be a solid catalyst for copolymerization reactions and also has been used in the synthesis of polymers with ethyl groups, hydroxyl groups, and active methylene groups.  Its regulatory properties are related to its valency and stereoisomers. 3,5-Dibromo-1H-pyrazole can be found in Alzheimer's disease as a quaternary ammonium salt.

Synthesis Reference(s)

[1] Huettel; Schoen [Justus Liebigs Annalen der Chemie, 1959, vol. 625, p. 55,60.

Safety

3,5-Dibromo-1H-pyrazole is irritating to the skin and eyes. In addition, it is acutely toxic.

Synthesis

The 3,5-dibromo-1H-pyrazole-4-carboxylic acid was treated with trifluorosulfonic anhydride to yield sulphonate, and the bromo-benzene was treated with bromine water, the corresponding Grignard reagent was prepared, then the benzene ring was hydrolyzed, to yield the product 3,5-Dibromo-1H-pyrazole [1].