3,4',5-TRIMETHOXY-TRANS-STILBENE

Synonym(s):1,3-dimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene; Tri-O-methylresveratrol; Trimethoxy-trans-stilbene

CAS NO.：22255-22-7
Empirical Formula: C17H18O3
Molecular Weight: 270.32
MDL number: MFCD02093500
EINECS: 694-659-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 22:43:18

3,4',5-TRIMETHOXY-TRANS-STILBENE Structural

What is 3,4',5-TRIMETHOXY-TRANS-STILBENE?

Description

trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC₅₀s =3.6, 10.2, 16.1, 54, and 2.5 μM, respectively). trans-trismethoxy Resveratrol (15 μM) inhibits TNF-α-induced activation of NF-κB in HEK293T cells in a reporter assay. It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 μM.

Chemical properties

Pale Yellow Oil

The Uses of 3,4',5-TRIMETHOXY-TRANS-STILBENE

A resveratrol analog with a variety of pharmacology action, including anti-cancer properties, anti-allergic activity, estrogenic activity, antiangiogenic activity, and vascular-targeting activity against microtubule-destabilization

The Uses of 3,4',5-TRIMETHOXY-TRANS-STILBENE

A resveratrol analog with a variety of pharmacology action, including inst microtubule-destabilization

The Uses of 3,4',5-TRIMETHOXY-TRANS-STILBENE

Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health. Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.

What are the applications of Application

3,5,4′-Trimethoxystilbene is an antiangiogenic agent that is shown to inhibit endothelial cell proliferation

Properties of 3,4',5-TRIMETHOXY-TRANS-STILBENE

Melting point:	57°C
Boiling point:	423.8±35.0 °C(Predicted)
Density	1.104±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: ≥34mg/mL
form	powder to crystal
color	white to tan
CAS DataBase Reference	22255-22-7

Safety information for 3,4',5-TRIMETHOXY-TRANS-STILBENE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.