3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Synonym(s):KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem;
- CAS NO.：199666-03-0
- Empirical Formula: C17H15N3O6S2
- Molecular Weight: 421.45
- MDL number: MFCD11040807
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:22:56
![3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Structural](https://img.chemicalbook.in/CAS/GIF/199666-03-0.gif)
What is 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide?
The Uses of 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Ro 61-8048 is a potent and competitive kynurenine 3-monooxygenase (KMO) inhibitor.
What are the applications of Application
Ro 61-8048 is a potent and competitive kynurenine 3-hydroxylase (KMO) inhibitor
Definition
ChEBI: Ro 61-8048 is a C-nitro compound.
Biological Activity
Potent and competitive kynurenine 3-hydroxylase inhibitor (K i = 4.8 nM, IC 50 = 37 nM). Increases kynurenic acid levels to concentrations that antagonize the glycine site of NMDA receptors. Brain penetrant and exhibits antidystonic, anticonvulsant and neuroprotective activities.
Biochem/physiol Actions
Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.
Storage
+4°C
Properties of 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
| Melting point: | 185℃ |
| Boiling point: | 627.4±65.0 °C(Predicted) |
| Density | 1.471±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥15mg/mL |
| pka | 6.29±0.10(Predicted) |
| form | Yellow solid |
| color | faint yellow to yellow |
Safety information for 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
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