3,4-Dimethoxy-3-cyclobutene-1,2-dione
Synonym(s):Dimethyl squarate
- CAS NO.：5222-73-1
- Empirical Formula: C6H6O4
- Molecular Weight: 142.11
- MDL number: MFCD00101316
- EINECS: 627-380-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:02:03
What is 3,4-Dimethoxy-3-cyclobutene-1,2-dione?
Chemical properties
white crystalline powder
The Uses of 3,4-Dimethoxy-3-cyclobutene-1,2-dione
3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) finds it uses in the synthesis of chiral squaramides, highly enantioselective catalyst for the Friedel-Crafts reactions of indoles, 3-(hydroxyamino)-4-methoxy-3-cyclobutene-1,2-dione, squarate derivatives of the O-SP-core antigens, methyl squarate derivative of the Ogawa O-SP-core antigen, o-quinodimethanes, benzocyclobutenes, quinones. It is employed as a starting material in the preparation of o-quinodimethanes, benzocyclobutenes, and quinones.
General Description
3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) is a cyclobutene derivative. It reacts with hydroxylamine derivatives to afford 3-hydroxyamino-4-methoxy-3-cyclobutene-1,2-diones.
Properties of 3,4-Dimethoxy-3-cyclobutene-1,2-dione
| Melting point: | 55-57 °C (lit.) |
| Boiling point: | 219.65°C (rough estimate) |
| Density | 1.3863 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO, Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Brown |
| Water Solubility | Very soluble in water. |
| CAS DataBase Reference | 5222-73-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 3,4-Dimethoxy-3-cyclobutene-1,2-dione(5222-73-1) |
Safety information for 3,4-Dimethoxy-3-cyclobutene-1,2-dione
| Signal word | Danger |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for 3,4-Dimethoxy-3-cyclobutene-1,2-dione
| InChIKey | SZBNZTGCAMLMJY-UHFFFAOYSA-N |
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