3-Methoxy-4-methylaniline

Synonym(s):o-Cresidine;4-Methyl-m-anisidine

CAS NO.：16452-01-0
Empirical Formula: C8H11NO
Molecular Weight: 137.18
MDL number: MFCD00025371
EINECS: 240-500-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:52:16

What is 3-Methoxy-4-methylaniline?

The Uses of 3-Methoxy-4-methylaniline

3-Methoxy-4-methylaniline, afforded by an electrophilic substitution, using the 2-methoxy-substituted iron complex sail followed by oxidative cyclization with concomitant aromation of the resulting iron complex. It is used to produce 8-methoxy-7-methylalloxazine. This reaction will need solvent ethanol, H2O

General Description

Brown chunky solid.

Air & Water Reactions

Sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

3-METHOXY-4-METHYLANILINE neutralizes acids in weakly exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents .

Fire Hazard

3-METHOXY-4-METHYLANILINE is probably combustible.

Properties of 3-Methoxy-4-methylaniline

Melting point:	57-59 °C
Boiling point:	252.03°C (rough estimate)
Density	1.0630 (rough estimate)
refractive index	1.5647 (estimate)
Flash point:	>113℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Solid
pka	4.61±0.10(Predicted)
color	Brown
Water Solubility	Insoluble in water.
CAS DataBase Reference	16452-01-0(CAS DataBase Reference)
EPA Substance Registry System	3-Methoxy-4-methylaniline (16452-01-0)

Safety information for 3-Methoxy-4-methylaniline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.