3-Ethoxy-1-propanol

CAS NO.：111-35-3
Empirical Formula: C5H12O2
Molecular Weight: 104.15
MDL number: MFCD00002948
EINECS: 203-861-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-16 09:55:24

What is 3-Ethoxy-1-propanol?

Chemical properties

colourless liquid

The Uses of 3-Ethoxy-1-propanol

3-??Ethoxy-??1-??propanol is used in the synthesis of [1,2,4]triazolo[1,5-a]pyrimidines as anticancer agents. It is also used to prepare N-substituted [(carboxymethyl)phenoxy]ethyl benzoxazinones as PPARγ agonists and antidiabetic (type 2) agents.

What are the applications of Application

3-Ethoxy-1-propanol is a useful alcohol for proteomics research

Definition

ChEBI: A hydroxyether that is propan-1-ol substituted by an ethoxy group at position 3.

General Description

A clear colorless liquid, with a mild odor. Less dense than water. Contact may slightly irritate skin, eyes and mucous membranes.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

3-Ethoxy-1-propanol is an ethoxy-alcohol derivative. The ether is relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fire Hazard

3-Ethoxy-1-propanol is combustible.

Properties of 3-Ethoxy-1-propanol

Melting point:	-90°C (estimate)
Boiling point:	160-161 °C(lit.)
Density	0.904 g/mL at 25 °C(lit.)
refractive index	n20/D 1.417(lit.)
Flash point:	130 °F
pka	14.90±0.10(Predicted)
Specific Gravity	0.904
Odor	fruit
Water Solubility	>=10 g/100 mL at 18 º
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	111-35-3(CAS DataBase Reference)
NIST Chemistry Reference	1-Propanol, 3-ethoxy-(111-35-3)
EPA Substance Registry System	3-Ethoxy-1-propanol (111-35-3)

Safety information for 3-Ethoxy-1-propanol

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.