3-Ethoxy-1-propanol
- CAS NO.：111-35-3
- Empirical Formula: C5H12O2
- Molecular Weight: 104.15
- MDL number: MFCD00002948
- EINECS: 203-861-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:44
What is 3-Ethoxy-1-propanol?
Chemical properties
colourless liquid
The Uses of 3-Ethoxy-1-propanol
3-??Ethoxy-??1-??propanol is used in the synthesis of [1,2,4]triazolo[1,5-a]pyrimidines as anticancer agents. It is also used to prepare N-substituted [(carboxymethyl)phenoxy]ethyl benzoxazinones as PPARγ agonists and antidiabetic (type 2) agents.
What are the applications of Application
3-Ethoxy-1-propanol is a useful alcohol for proteomics research
Definition
ChEBI: A hydroxyether that is propan-1-ol substituted by an ethoxy group at position 3.
General Description
A clear colorless liquid, with a mild odor. Less dense than water. Contact may slightly irritate skin, eyes and mucous membranes.
Air & Water Reactions
Highly flammable. Water soluble.
Reactivity Profile
3-Ethoxy-1-propanol is an ethoxy-alcohol derivative. The ether is relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Fire Hazard
3-Ethoxy-1-propanol is combustible.
Properties of 3-Ethoxy-1-propanol
| Melting point: | -90°C (estimate) |
| Boiling point: | 160-161 °C(lit.) |
| Density | 0.904 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 130 °F |
| pka | 14.90±0.10(Predicted) |
| Specific Gravity | 0.904 |
| Odor | fruit |
| Water Solubility | >=10 g/100 mL at 18 º |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 111-35-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Propanol, 3-ethoxy-(111-35-3) |
| EPA Substance Registry System | 3-Ethoxy-1-propanol (111-35-3) |
Safety information for 3-Ethoxy-1-propanol
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Ethoxy-1-propanol
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