3-Amino-5-fluoropyridine
Synonym(s):(5-Fluoropyridin-3-yl)amine;3-Amino-5-fluoropyridine;5-Fluoropyridin-3-amine
- CAS NO.：210169-05-4
- Empirical Formula: C5H5FN2
- Molecular Weight: 112.11
- MDL number: MFCD00234073
- EINECS: 664-255-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:31
What is 3-Amino-5-fluoropyridine?
Chemical properties
Light yellow Crystal
The Uses of 3-Amino-5-fluoropyridine
3-amino-5-fluoropyridine is an important intermediate mainly used in medicine and organic synthesis. It is used to synthesize Ivosidenib. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults.
What are the applications of Application
Reactant for:
Preparation of nonpeptide inhibitors of measles virus entry.
Preparation
synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);
IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29.
Properties of 3-Amino-5-fluoropyridine
| Melting point: | 86°C |
| Boiling point: | 232.7±20.0 °C(Predicted) |
| Density | 1.257±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.74±0.20(Predicted) |
| color | Light orange to Yellow to Green |
| CAS DataBase Reference | 210169-05-4(CAS DataBase Reference) |
Safety information for 3-Amino-5-fluoropyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3-Amino-5-fluoropyridine
New Products
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![4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)-N-{[2-(TRIFLUOROMETHYL)PHENYL]SULFONYL}PIPERAZINE-1-CARBOXAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB4185596.gif)
![N-[(4-FLUOROPHENYL)SULFONYL]-4-(2,3,5,6-TETRAFLUOROPYRIDIN-4-YL)PIPERAZINE-1-CARBOXAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB7358254.gif)
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