3-Amino-2-chloro-4-methylpyridine
- CAS NO.：133627-45-9
- Empirical Formula: C6H7ClN2
- Molecular Weight: 142.59
- MDL number: MFCD00673152
- EINECS: 603-756-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:13:42
What is 3-Amino-2-chloro-4-methylpyridine?
Chemical properties
Off White Crystals
The Uses of 3-Amino-2-chloro-4-methylpyridine
3-Amino-2-chloro-4-methylpyridine, also known as CAPIC, is a key intermediate in the production of nevirapine, a non-nucleosidic reverse transcriptase inhibitor that has been established to be clinically useful for the treatment of infection by HIV-1.
Preparation
3-Amino-2-chloro-4-methylpyridine can be obtained by reacting 2-chloro-4-methylnicotinamide with strong bases and halides. 
Properties of 3-Amino-2-chloro-4-methylpyridine
| Melting point: | 65-70 °C |
| Boiling point: | 283.3±35.0 °C(Predicted) |
| Density | 1.260±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform, Ethanol |
| form | Crystals |
| pka | 3.22±0.10(Predicted) |
| color | Off White |
| InChI | InChI=1S/C6H7ClN2/c1-4-2-3-9-6(7)5(4)8/h2-3H,8H2,1H3 |
| CAS DataBase Reference | 133627-45-9(CAS DataBase Reference) |
Safety information for 3-Amino-2-chloro-4-methylpyridine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 3-Amino-2-chloro-4-methylpyridine
| InChIKey | UOBCYTOUXLAABU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CC(C)=C1N |
3-Amino-2-chloro-4-methylpyridine manufacturer
GK Chemicals
1Y
Phone:+91-7207279444
Whatsapp: +91-7207279444
product: 2-Chloro-4-methyl-3-amino pyridine 133627-45-9 98%
SAKEM LLP
1Y
Phone:+91-9676889998
Whatsapp: +91-9676889998
product: 133627-45-9 3-Amino-2-Chloro-4-Picoline 98%
Cynor Laboratories
Gujarat
product: 2 -Chloro-4-Methyl-3 -amino Pyridine(133627-45-9), Grade Standard: Industrial Grade
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