Ethyl (3-fluorobenzoyl)acetate
Synonym(s):(m-Fluorobenzoyl)acetic acid ethyl ester;3-(3-Fluorophenyl)-3-oxopropanoic acid ethyl ester;3-(3-Fluorophenyl)-3-oxo-propionic acid ethyl ester;Ethyl m-fluorobenzoyl acetate;Ethyl 2-3-fluorobenzoylacetate
- CAS NO.：33166-77-7
- Empirical Formula: C11H11FO3
- Molecular Weight: 210.2
- MDL number: MFCD03424809
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:56
What is Ethyl (3-fluorobenzoyl)acetate?
The Uses of Ethyl (3-fluorobenzoyl)acetate
Reactant for:
- Preparation of biologically active molecules
Synthesis
To a stirring suspension of NaH and CO(OEt)2 in toluene was added dropwise a solution of substituted acetophenone in toluene under reflux. The mixture was allowed to reflux and was stirred for 20 min after the addition was complete. When cooled to room temperature, the mixture was acidified with glacial HOAc. After ice-cold water was added, the mixture was extracted with toluene. The extract was then dried over anhydrous MgS04. After the toluene was evaporated in vacuo to give the corresponding substituted Ethyl (3-fluorobenzoyl)acetate.
Properties of Ethyl (3-fluorobenzoyl)acetate
| Boiling point: | 262-263 °C(lit.) |
| Density | 1.166 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 10.10±0.46(Predicted) |
| form | Liquid |
| color | Colorless to orange |
| CAS DataBase Reference | 33166-77-7(CAS DataBase Reference) |
Safety information for Ethyl (3-fluorobenzoyl)acetate
Computed Descriptors for Ethyl (3-fluorobenzoyl)acetate
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