PS 48

Synonym(s):5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

CAS NO.：1180676-32-7
Empirical Formula: C17H15ClO2
Molecular Weight: 286.75
MDL number: MFCD17215962
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:39:33

What is PS 48?

The Uses of PS 48

PS 48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator.

What are the applications of Application

PS 48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator

Biochem/physiol Actions

PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

Properties of PS 48

Melting point:	114-115℃
Boiling point:	444.1±24.0 °C(Predicted)
Density	1.225±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >20mg/mL
form	powder
pka	4.55±0.10(Predicted)
color	white to off-white

Safety information for PS 48

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for PS 48

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