(2S,4R)-4-METHYLGLUTAMIC ACID

Chemical properties

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The Uses of (2S,4R)-4-METHYLGLUTAMIC ACID

A highly selective and potent agonist for kainate receptors.

What are the applications of Application

(2S,4R)-4-Methylglutamic Acid is a kainate receptor agonist and EAAT2 inhibitor

Biological Activity

Potent and highly selective kainate receptor agonist, with an IC 50 for inhibition of [ 3 H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™ .