(2S,4R)-4-METHYLGLUTAMIC ACID
- CAS NO.：31137-74-3
- Empirical Formula: C6H11NO4
- Molecular Weight: 161.16
- MDL number: MFCD00937765
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-05 14:33:18
What is (2S,4R)-4-METHYLGLUTAMIC ACID?
Chemical properties
White
The Uses of (2S,4R)-4-METHYLGLUTAMIC ACID
A highly selective and potent agonist for kainate receptors.
What are the applications of Application
(2S,4R)-4-Methylglutamic Acid is a kainate receptor agonist and EAAT2 inhibitor
Biological Activity
Potent and highly selective kainate receptor agonist, with an IC 50 for inhibition of [ 3 H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™ .
Properties of (2S,4R)-4-METHYLGLUTAMIC ACID
| Melting point: | 178 °C |
| Boiling point: | 287.44°C (rough estimate) |
| Density | 1.3482 (rough estimate) |
| refractive index | 1.4230 (estimate) |
| storage temp. | Store at RT |
| solubility | H2O: >10 mg/mL |
| form | solid |
| pka | 2.34±0.21(Predicted) |
| color | white |
| CAS DataBase Reference | 31137-74-3(CAS DataBase Reference) |
Safety information for (2S,4R)-4-METHYLGLUTAMIC ACID
Computed Descriptors for (2S,4R)-4-METHYLGLUTAMIC ACID
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