(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

CAS NO.：1033805-28-5
Empirical Formula: C25H22ClF3N6O3
Molecular Weight: 546.93
MDL number: MFCD20528907
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

What is (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat?

The Uses of (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

Telotristat acts as a tryptophan hydroxylase (TPH) inhibitor.

Definition

ChEBI: Telotristat is a phenylalanine derivative.

Biological Activity

telotristat is the active metabolite of lx1606(telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (tph) inhibitor with potential antiserotonergic activity.

Properties of (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

Boiling point:	731.1±70.0 °C(Predicted)
Density	1.50±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	≥27.35 mg/mL in DMSO with ultrasonic; insoluble in H2O; insoluble in EtOH
form	Powder
pka	2.04±0.10(Predicted)
color	White to light yellow

Safety information for (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for (2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat

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