2,8-Quinolinediol

Synonym(s):2,8-Dihydroxyquinoline

CAS NO.：15450-76-7
Empirical Formula: C9H7NO2
Molecular Weight: 161.16
MDL number: MFCD00216696
EINECS: 604-962-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-17 10:44:43

What is 2,8-Quinolinediol?

Chemical properties

Brown Powder

The Uses of 2,8-Quinolinediol

2,8-Quinolinediol is a substituted quinolinone derivative used in the preparation of pharmaceutical compounds.

The Uses of 2,8-Quinolinediol

2,8-Quinolinediol is suitable for use as standard in a study to identify the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats by online and off-line LC-MS techniques. It may be used as starting reagent for the preparation of two powerful β2-adrenergic receptor agonists, used for the treatment of asthma:

Procaterol
Indacaterol

Definition

ChEBI: Quinoline-2,8-diol is a dihydroxyquinoline. It is a tautomer of an 8-hydroxyquinolin-2(1H)-one.

General Description

2,8-Quinolinediol is a quinolone derivative. It has been reported as metabolite of 8-hydroxyquinoline-N-oxide in rabbits. Synthesis of 2,8-quinolinediol has been reported. It is reported as one of the six possible forms of 8-hydroxycarbostyril. It has been detected as new UV-absorbing compound (UAC) in cow milk and its structure was elucidated using HRMS and by ¹H, ¹³C and ¹H ×¹³C NMR.It is also known as 8-hydroxycarbostyril or 8-hydroxyquinolin-2(1H)-one.

Properties of 2,8-Quinolinediol

Melting point:	~290 °C (dec.)
Boiling point:	403.2±45.0 °C(Predicted)
Density	1.337±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	8.85±0.20(Predicted)
color	Dark Reddish Brown
λmax	335nm(EtOH)(lit.)
BRN	472906
CAS DataBase Reference	15450-76-7(CAS DataBase Reference)

Safety information for 2,8-Quinolinediol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.