2',6'-DIMETHYLACETANILIDE
Synonym(s):2′,6′-Acetoxylidide;2′,6′-Dimethylacetanilide
- CAS NO.：2198-53-0
- Empirical Formula: C10H13NO
- Molecular Weight: 163.22
- MDL number: MFCD00008675
- EINECS: 218-596-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:56
What is 2',6'-DIMETHYLACETANILIDE?
Chemical properties
off-white to yellow cryst. needles or cryst.powder
The Uses of 2',6'-DIMETHYLACETANILIDE
Lidocaine (L397800) impurity.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073
Chemical and Pharmaceutical Bulletin, 30, p. 4242, 1982 DOI: 10.1248/cpb.30.4242
Journal of Heterocyclic Chemistry, 2, p. 181, 1965 DOI: 10.1002/jhet.5570020214
General Description
2,6-Dimethylacetanilide undergoes iodination by electrophylic substitution reaction of chloroacetanilide, in the presence of ferroiodide and copperchloride as catalyst, to form 4-iodine-2,6-dimethylacetanilide.
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes ofNOx.
Properties of 2',6'-DIMETHYLACETANILIDE
| Melting point: | 182-184 °C(lit.) |
| Boiling point: | 290.31°C (rough estimate) |
| Density | 1.052 |
| refractive index | 1.5400 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 15.14±0.70(Predicted) |
| color | Crystals |
| CAS DataBase Reference | 2198-53-0(CAS DataBase Reference) |
| EPA Substance Registry System | Acetamide, N-(2,6-dimethylphenyl)- (2198-53-0) |
Safety information for 2',6'-DIMETHYLACETANILIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2',6'-DIMETHYLACETANILIDE
2',6'-DIMETHYLACETANILIDE manufacturer
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product: LIDOCAINE EP IMPURITY C 2198-53-0 90 % Above
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