2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
- CAS NO.：865305-30-2
- Empirical Formula: C14H17IN4O2
- Molecular Weight: 400.21
- MDL number: MFCD18782750
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-05 08:30:42
![2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Structural](https://img.chemicalbook.in/CAS/GIF/865305-30-2.gif)
What is 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-?
Description
AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.
Properties of 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
| Boiling point: | 510.2±60.0 °C(Predicted) |
| Density | 1.619±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 32 mg/mL (79.96 mM) |
| form | Solid |
| pka | 6.89±0.10(Predicted) |
| color | Light brown to brown |
Safety information for 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
Computed Descriptors for 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- manufacturer
ALS India Life Sciences Pvt. Ltd
2Y
Phone:+91-8977036378
Whatsapp: +91 8008166674
product: 5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine 92.40%
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