2,4-Difluoronitrobenzene

Synonym(s):2,4-Difluoro-1-nitrobenzene

CAS NO.：446-35-5
Empirical Formula: C6H3F2NO2
Molecular Weight: 159.09
MDL number: MFCD00007050
EINECS: 207-167-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:17

What is 2,4-Difluoronitrobenzene?

Chemical properties

yellow liquid

The Uses of 2,4-Difluoronitrobenzene

2,4-Difluoronitrobenzene has been used in the synthesis of: 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction; (±)-horsfiline; resin-bound 2-arylaminobenzimidazoles.
2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents.

The Uses of 2,4-Difluoronitrobenzene

2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.

The Uses of 2,4-Difluoronitrobenzene

2,4-Difluoronitrobenzene has been used in the synthesis of:

2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
(±)-horsfiline
resin-bound 2-arylaminobenzimidazoles

General Description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

Properties of 2,4-Difluoronitrobenzene

Melting point:	9-10 °C (lit.)
Boiling point:	203-204 °C (lit.)
Density	1.451 g/mL at 25 °C (lit.)
vapor density	>1 (vs air)
refractive index	n20/D 1.511(lit.)
Flash point:	195 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	Light yellow to Brown
Specific Gravity	1.45
Water Solubility	Insoluble in water.
BRN	2048034
Stability:	Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference	446-35-5(CAS DataBase Reference)
NIST Chemistry Reference	2,4-Difluoronitrobenzene(446-35-5)
EPA Substance Registry System	2,4-Difluoronitrobenzene (446-35-5)

Safety information for 2,4-Difluoronitrobenzene

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.