2,4-Difluoronitrobenzene
Synonym(s):2,4-Difluoro-1-nitrobenzene
- CAS NO.:446-35-5
- Empirical Formula: C6H3F2NO2
- Molecular Weight: 159.09
- MDL number: MFCD00007050
- EINECS: 207-167-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:04
What is 2,4-Difluoronitrobenzene?
Chemical properties
yellow liquid
The Uses of 2,4-Difluoronitrobenzene
2,4-Difluoronitrobenzene has been used in the synthesis of:
2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction;
(±)-horsfiline;
resin-bound 2-arylaminobenzimidazoles.
2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents.
The Uses of 2,4-Difluoronitrobenzene
2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.
The Uses of 2,4-Difluoronitrobenzene
2,4-Difluoronitrobenzene has been used in the synthesis of:
- 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
- (±)-horsfiline
- resin-bound 2-arylaminobenzimidazoles
General Description
Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.
Properties of 2,4-Difluoronitrobenzene
| Melting point: | 9-10 °C (lit.) |
| Boiling point: | 203-204 °C (lit.) |
| Density | 1.451 g/mL at 25 °C (lit.) |
| vapor density | >1 (vs air) |
| refractive index | n |
| Flash point: | 195 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | clear liquid |
| color | Light yellow to Brown |
| Specific Gravity | 1.45 |
| Water Solubility | Insoluble in water. |
| BRN | 2048034 |
| Stability: | Stable. Incompatible with strong bases, strong oxidizing agents. Combustible. |
| CAS DataBase Reference | 446-35-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,4-Difluoronitrobenzene(446-35-5) |
| EPA Substance Registry System | 2,4-Difluoronitrobenzene (446-35-5) |
Safety information for 2,4-Difluoronitrobenzene
| Signal word | Danger |
| Pictogram(s) |
![]() Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,4-Difluoronitrobenzene
| InChIKey | RJXOVESYJFXCGI-UHFFFAOYSA-N |
2,4-Difluoronitrobenzene manufacturer
ASM Organics
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