2,4-Dichloronitrobenzene

Synonym(s):1,3-Dichloro-4-nitrobenzene;2,4-Dichloro-1-nitrobenzene, 1-Nitro-2.4-dichlorine benzene;asym.-Nitro-m-dichlorobenzene

yellow crystals

2,4-Dichloro-1-nitrobenzene is used as a reagent in the synthesis of the hepatitis C virus polymerase inhibitor, Deleobuvir (BI 207127).

1,3-Dichlorobenzene is nitrated with mixed acid, and the product 2,4-Dichloronitrobenzene is separated from the resulting isomer mixture.

Light yellow needles or amber crystalline solid.

Insoluble in water.

Can react vigorously with oxidizing materials.

2,4-Dichloronitrobenzene is combustible.

Melting point:	29-32 °C(lit.)
Boiling point:	258 °C(lit.)
Density	1.479
vapor pressure	0.013 hPa (20 °C)
refractive index	1.5512 (estimate)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	188g/l
form	Crystalline Low Melting Solid
color	Yellow-brown
Water Solubility	188 mg/L (20 ºC)
BRN	1451655
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference	611-06-3(CAS DataBase Reference)
IARC	2B (Vol. 123) 2020
NIST Chemistry Reference	Benzene, 2,4-dichloro-1-nitro-(611-06-3)
EPA Substance Registry System	2,4-Dichloronitrobenzene (611-06-3)

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H311:Acute toxicity,dermal H317:Sensitisation, Skin H341:Germ cell mutagenicity H350:Carcinogenicity H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention.