2,4-Dichloro-5-methylpyridine

CAS NO.：56961-78-5
Empirical Formula: C6H5Cl2N
Molecular Weight: 162.02
MDL number: MFCD08704813
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 16:04:00

What is 2,4-Dichloro-5-methylpyridine?

Chemical properties

colorless liquid

The Uses of 2,4-Dichloro-5-methylpyridine

2,4-Dichloro-5-methylpyridine is used as pharmaceutical intermediates.

Synthesis

A solution of phosphorus oxychloride in dichloromethane was added to a mixture of 2-chloro-5-methylpyridine 1-oxide and triethylamine in dichloromethane at 0 ℃. After stirring for 2 hours, the mixture is reacted at room temperature for 24 hours. After that, the water was added and the mixture was neutralized with a sodium hydroxide solution. The organic layer was washed with a saturated brine solution and the aqueous layer was extracted with ethyl acetate and washed with a saturated brine solution. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 2,4-Dichloro-5-methylpyridine. The by-product of this reaction is 2,6-dichloro-3-methyl-pyridine.

Properties of 2,4-Dichloro-5-methylpyridine

Boiling point:	221.2±35.0 °C(Predicted)
Density	1.319±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	0.38±0.10(Predicted)
form	Liquid
color	Colorless
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C6H5Cl2N/c1-4-3-9-6(8)2-5(4)7/h2-3H,1H3

Safety information for 2,4-Dichloro-5-methylpyridine

Signal word	Warning
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H301:Acute toxicity,oral H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.