2,4-Dichloro-5-methylpyridine
- CAS NO.：56961-78-5
- Empirical Formula: C6H5Cl2N
- Molecular Weight: 162.02
- MDL number: MFCD08704813
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:12
What is 2,4-Dichloro-5-methylpyridine?
Chemical properties
colorless liquid
The Uses of 2,4-Dichloro-5-methylpyridine
2,4-Dichloro-5-methylpyridine is used as pharmaceutical intermediates.
Synthesis
A solution of phosphorus oxychloride in dichloromethane was added to a mixture of 2-chloro-5-methylpyridine 1-oxide and triethylamine in dichloromethane at 0 ℃. After stirring for 2 hours, the mixture is reacted at room temperature for 24 hours. After that, the water was added and the mixture was neutralized with a sodium hydroxide solution. The organic layer was washed with a saturated brine solution and the aqueous layer was extracted with ethyl acetate and washed with a saturated brine solution. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 2,4-Dichloro-5-methylpyridine. The by-product of this reaction is 2,6-dichloro-3-methyl-pyridine.
Properties of 2,4-Dichloro-5-methylpyridine
| Boiling point: | 221.2±35.0 °C(Predicted) |
| Density | 1.319±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 0.38±0.10(Predicted) |
| form | Liquid |
| color | Colorless |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C6H5Cl2N/c1-4-3-9-6(8)2-5(4)7/h2-3H,1H3 |
Safety information for 2,4-Dichloro-5-methylpyridine
| Signal word | Warning |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2,4-Dichloro-5-methylpyridine
| InChIKey | DUPJNQNLAKJWKU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(C)C(Cl)=C1 |
2,4-Dichloro-5-methylpyridine manufacturer
SGT life sciences
4Y
Phone:+91-9866957562
Whatsapp: +91- 9866957562
product: 56961-78-5 2,4 Dichloro-5-methyl pyridine 99%+
Ina pharmaceuticals Pvt Ltd
3Y
Phone:+91-7815933367
Whatsapp: +91-78159 33367
product: 56961-78-5 2,4-Dichloro-5-Methylpyridine 99%
PRODEV PHARMA (OPC) PRIVATE LIMITED
3Y
Phone:+919849892844
Whatsapp: +91-9849892844
product: 2,4-Dichloro-5-methylpyridine (or) 2,4-Dichloro-5-picoline 98%
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