2,2,5,7,8-PENTAMETHYL-6-CHROMANOL
- CAS NO.：950-99-2
- Empirical Formula: C14H20O2
- Molecular Weight: 220.31
- MDL number: MFCD00210347
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:55
What is 2,2,5,7,8-PENTAMETHYL-6-CHROMANOL?
The Uses of 2,2,5,7,8-PENTAMETHYL-6-CHROMANOL
2,2,5,7,8-Pentamethyl-6-chromanol is the suitable reagent used for the quantitative analysis of α-tocopherol by plasma-based gas chromatography/tandem mass spectrometry (GC/MS/MS) using a tabletop quadrupole ion trap mass spectrometer. It may be employed as α-tocopherol model compound and on oxidation by t-butyl hydroperoxide in chloroform, in the presence of alcohol, affords 5-alkoxymethyl-2,2,7,8-tetramethyl-6-chromanol. It may be used as internal standard for the determination of α- and γ-tocopherol in the rabbit serum and liver by HPLC.
General Description
2,2,5,7,8-Pentamethyl-6-chromanol has been reported as an vitamin E model compound. It undergoes oxidation in presence of various alcohols, ranging from methanol to cholesterol, affords 5-alkoxymethyl-2,2,7,8-tetramethyl-6-chromanols. Antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol (PMCol), is reported to have antiandrogen activity in prostate carcinoma cells.
Properties of 2,2,5,7,8-PENTAMETHYL-6-CHROMANOL
| Melting point: | 89-91 °C (lit.) |
| Boiling point: | 344.3±42.0 °C(Predicted) |
| Density | 1.034±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 250 mg/mL (1134.76 mM) |
| pka | 11.41±0.40(Predicted) |
| color | White |
Safety information for 2,2,5,7,8-PENTAMETHYL-6-CHROMANOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,2,5,7,8-PENTAMETHYL-6-CHROMANOL
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