2,2,2-Trichloroethyl chloroformate
Synonym(s):2,2,2-Trichloroethoxycarbonyl chloride
- CAS NO.：17341-93-4
- Empirical Formula: C3H2Cl4O2
- Molecular Weight: 211.86
- MDL number: MFCD00000810
- EINECS: 241-363-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:34:17
What is 2,2,2-Trichloroethyl chloroformate?
Chemical properties
Clear light yellow liquid
The Uses of 2,2,2-Trichloroethyl chloroformate
2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.
The Uses of 2,2,2-Trichloroethyl chloroformate
2,2,2-Trichloroethyl chloroformate was used as:
- derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples
- starting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)
- reagent during N-demethylation of dextromethorphan
- protecting group reagent for amines and alcohols
What are the applications of Application
2,2,2-Trichloroethyl chloroformate is a protecting reagent for aliphatic and aromatic hydroxyl and amino groups
Properties of 2,2,2-Trichloroethyl chloroformate
| Melting point: | 1°C |
| Boiling point: | 171-172 °C (lit.) |
| Density | 1.539 g/mL at 25 °C (lit.) |
| vapor pressure | 0.06 psi ( 20 °C) |
| refractive index | n |
| Flash point: | >100°C |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, Ethyl Acetate |
| form | Liquid |
| color | Clear light yellow |
| Water Solubility | Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 970619 |
| CAS DataBase Reference | 17341-93-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Carbonochloridic acid, 2,2,2-trichloroethyl ester(17341-93-4) |
| EPA Substance Registry System | Carbonochloridic acid, 2,2,2-trichloroethyl ester (17341-93-4) |
Safety information for 2,2,2-Trichloroethyl chloroformate
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H331:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for 2,2,2-Trichloroethyl chloroformate
| InChIKey | LJCZNYWLQZZIOS-UHFFFAOYSA-N |
2,2,2-Trichloroethyl chloroformate manufacturer
Ina pharmaceuticals Pvt Ltd
3Y
Phone:+91-7815933367
Whatsapp: +91-78159 33367
product: 17341-93-4 2,2,2-Trichloroethyl chloroformate 99%
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: 2,2,2-Trichloroethyl Chloroformate
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