2,2-Diethoxypropane
Synonym(s):2,2-Diethoxypropane;Acetone diethyl acetal
- CAS NO.:126-84-1
- Empirical Formula: C7H16O2
- Molecular Weight: 132.2
- MDL number: MFCD00009224
- EINECS: 204-808-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:58
What is 2,2-Diethoxypropane ?
The Uses of 2,2-Diethoxypropane
Ethereal-camphorlike odor. Probably not used in flavors.Occasionally used in perfumes to introduce diffusive topnotes in herbaceous-camphoraceous blends (Lavandin-Rosemary, etc.).
Preparation
To a flask equipped as in Preparation 2-11 and containing 1725 gm (37.5 moles) of ethanol, 18.4 gm (0.058 mole) of mercuric acetate, and 28 ml of 26% boron fluoride etherate (26%) at 30°C is added dropwise over a 15 min period at 45-50°C, 1250 gm (12.5 moles) of isopropenyl acetate. After the reaction 2200 gm of 25% sodium hydroxide is added, the organic layer separated, washed first with 400 ml of 0.01 Ν sodium hydroxide, dried, and distilled to afford 1140 gm (69%), b.p. 110-113 C (760 mm Hg).

Production Methods
2,2-Diethoxypropane can be produced by synthesis via orthoformic ester, or via vinyl ether, or via formiminoethylether hydrochloride.
Safety Profile
Poison by intraperitoneal route.When heated to decomposition it emits acrid smoke.
Solubility in organics
Soluble in alcohol, miscible with CSS.oils and perfume chemicals.
Properties of 2,2-Diethoxypropane
| Boiling point: | 116-117 °C (lit.) |
| Density | 0.82 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 46 °F |
| storage temp. | 2-8°C |
| form | clear liquid |
| color | Colorless to Almost colorless |
| CAS DataBase Reference | 126-84-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Propane, 2,2-diethoxy-(126-84-1) |
| EPA Substance Registry System | Propane, 2,2-diethoxy- (126-84-1) |
Safety information for 2,2-Diethoxypropane
| Signal word | Danger |
| Pictogram(s) |
![]() Flame Flammables GHS02 |
| GHS Hazard Statements |
H225:Flammable liquids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. |
Computed Descriptors for 2,2-Diethoxypropane
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