2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE
Synonym(s):1-Formylethylidenetriphenylphosphorane
- CAS NO.：24720-64-7
- Empirical Formula: C21H19OP
- Molecular Weight: 318.35
- MDL number: MFCD00075596
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-19 07:28:27
What is 2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE?
Chemical properties
White to light beige crystalline powder
The Uses of 2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE
2-(Triphenylphosphoranylidene)propionaldehyde is a reagent used in the asymmetric synthesis of hispidanin A via oxidative alkoxylation and stereoselective Diels-Alder reaction. Also acts as a reagent in the stereoselective synthesis of 10-epi-tirandamycin E.
The Uses of 2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE
Reactant for:• ;Preparation of acitretin analogs with antitumor activity1• ;Stereoselective synthesis of essential building blocks of phorboxazole A via hetero Diels-Alder and stereoselective hetero-Michael addition/equilibration2• ;Preparation of C1-C14 fragment of sarcoglaucol-16-one via Z-selective ando-type Horner-Wadsworth-Emmons olefination3• ;Wittig reactions4• ;Synthesis of ring-expanded and epothilone-hybridized macrosphelide analogs as apoptosis-inducing agents5• ;Preparation of phosphonic acid-containing analogs of mycophenolic acid as inhibitors
The Uses of 2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE
Reactant for:
- Preparation of acitretin analogs with antitumor activity
- Stereoselective synthesis of essential building blocks of phorboxazole A via hetero Diels-Alder and stereoselective hetero-Michael addition/equilibration
- Preparation of C1-C14 fragment of sarcoglaucol-16-one via Z-selective ando-type Horner-Wadsworth-Emmons olefination
- Wittig reactions
- Synthesis of ring-expanded and epothilone-hybridized macrosphelide analogs as apoptosis-inducing agents
- Preparation of phosphonic acid-containing analogs of mycophenolic acid as inhibitors of IMPDH
Properties of 2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE
| Melting point: | 219-221 °C (lit.) |
| Boiling point: | 478.5±28.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | Low Melting Solid |
| color | White to pink to brown |
| CAS DataBase Reference | 24720-64-7 |
Safety information for 2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(TRIPHENYLPHOSPHORANYLIDENE)PROPIONALDEHYDE
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