2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
Synonym(s):SEM-triphenylphosphonium chloride
- CAS NO.：82495-75-8
- Empirical Formula: C24H30ClOPSi
- Molecular Weight: 429.01
- MDL number: MFCD00043159
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE?
Physical properties
mp 165–169 °C.
The Uses of 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
2-(Trimethylsilyl)ethoxymethyltriphenylphosphonium Chloride is used in preparation of Benzodecalindiones as antitumor agents.
The Uses of 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
[2-(Trimethylsilyl)ethoxymethyl]- triphenylphosphonium chloride is a reagent undergoes deprotonation and yield formation permitting the construction of enol ethers from aldehydes and ketones.
Preparation
Involves reaction of triphenylphosphine with 2-(trimethylsilyl)ethoxymethyl chloride in benzene at gentle reflux for 18 h. Upon cooling, the resulting phosphonium salt can be recovered by filtration and purified by triturating with diethyl ether in 94% yield.
Purification Methods
Wash the solid with AcOH and recrystallise it from CH2Cl2/EtOAc. Dry it in a vacuum desiccator. Hygroscopic. 1H NMR (CDCl3) : -0.2 (s, Me3Si), 0.8 (t, 8Hz, CH2Si), 3.83 (t, 8Hz, OCH2), 5.77 (d, JPH 4Hz, P+-CH2O) and 7.70 (m, aromatic H). [Sch.nauer & Zbiral Justus Liebigs Ann Chem 1039 1983.]
Properties of 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
| Melting point: | 145-149 °C(lit.) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Sol H2O and dichloromethane; sparingly soluble in
THF. |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 4632507 |
| CAS DataBase Reference | 82495-75-8(CAS DataBase Reference) |
Safety information for 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(TRIMETHYLSILYL)ETHOXYMETHYLTRIPHENYLPHOSPHONIUM CHLORIDE
New Products
4-Bromo-2-chlorobenzonitrile 1-Chloro-4-Methyl-2-Nitrobenzene 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile Chlorodehydromethyl testosterone Cisplatin Prednisolone acetate Trenbolone Enanthate Benzethonium Chloride Testosterone acetate 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 3-Hydroxy-4-nitrobromobenzene 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Boc-L-Leucinol Calcium Ascorbate Boc-Tyr-OH tert-butyl 2-oxo-1,4,9-triazaspiro[5.5]undecane-9-carboxylate 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-1H-pyrazole-4-carboxylic acid (1R,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-oneRelated products of tetrahydrofuran
You may like
-
2-(Trimethylsilyl)ethoxymethyltriphenylphosphonium Chloride CAS 82495-75-8View Details
82495-75-8 -
2124221-11-8 (4-(methylamino)phenyl)methanesulfonic acid 98%View Details
2124221-11-8 -
Boc-Arg-OH HCl H2O 114622-81-0 98%View Details
114622-81-0 -
2-(2-chloropyrimidin-4-yl)acetic acid 98%View Details
1211581-39-3 -
15761-38-3 Boc-Ala-OH 98%View Details
15761-38-3 -
42074-68-0 98%View Details
42074-68-0 -
20866-46-0 Boc-His(Boc)-OH 98%View Details
20866-46-0 -
2-(4-(tert-butoxycarbonyl)piperazin-2-yl)acetic acid 98%View Details
183591-72-2