2-(Trifluoromethyl)pyridine
Synonym(s):α,α,α-Trifluoro-2-picoline
- CAS NO.：368-48-9
- Empirical Formula: C6H4F3N
- Molecular Weight: 147.1
- MDL number: MFCD02183562
- EINECS: 626-032-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:13
What is 2-(Trifluoromethyl)pyridine?
The Uses of 2-(Trifluoromethyl)pyridine
Lithiation with n-BuLi/LiOCH2CH2NMe2?takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP?. It is a building block in heterocycle synthesis.
Synthesis Reference(s)
Synthesis, p. 932, 1980 DOI: 10.1055/s-1980-29276
Properties of 2-(Trifluoromethyl)pyridine
| Boiling point: | 139-141 °C |
| Density | 1.275 g/mL at 25 °C |
| refractive index | n |
| Flash point: | 109 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in most organic solvents. |
| form | clear liquid |
| pka | 0.60±0.12(Predicted) |
| color | Colorless to Light yellow |
| BRN | 3112 |
| CAS DataBase Reference | 368-48-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-(CF3)-pyridine(368-48-9) |
Safety information for 2-(Trifluoromethyl)pyridine
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(Trifluoromethyl)pyridine
| InChIKey | ATRQECRSCHYSNP-UHFFFAOYSA-N |
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