2-Tetrahydrofuroic acid
Synonym(s):Tetrahydrofuran-2-carboxylic acid
- CAS NO.：16874-33-2
- Empirical Formula: C5H8O3
- Molecular Weight: 116.12
- MDL number: MFCD00022473
- EINECS: 605-530-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 18:07:46
What is 2-Tetrahydrofuroic acid?
Chemical properties
Colorless to light yellow liqui
The Uses of 2-Tetrahydrofuroic acid
2-Tetrahydrofuroic acid is used as a reagent to synthesize Alfuzosin (HCl: A532000), an unselective alpha-1 blocker that is used to treat lower urinary tract symptoms and benign prostatic hyperplasia.
What are the applications of Application
Tetrahydro-2-furoic acid is a specific PRODH (proline dehydrogenase) inhibitor
General Description
Tetrahydro-2-furoic acid inhibits the programmed cell death of Xanthomonas campestris strains. It is a specific inhibitor of proline dehydrogenase, a mitochondrial flavoenzyme that oxidizes proline.
Properties of 2-Tetrahydrofuroic acid
| Melting point: | 21°C |
| Boiling point: | 128-129 °C13 mm Hg(lit.) |
| Density | 1.209 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 139 °C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 3.60±0.20(Predicted) |
| form | Liquid |
| color | Clear yellow to brown |
| Water Solubility | soluble |
| BRN | 109671 |
| CAS DataBase Reference | 16874-33-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Furancarboxylic acid, tetrahydro-(16874-33-2) |
| EPA Substance Registry System | 2-Furancarboxylic acid, tetrahydro- (16874-33-2) |
Safety information for 2-Tetrahydrofuroic acid
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Tetrahydrofuroic acid
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