2-Phenoxyethylbromide
Synonym(s):2-Bromoethyl phenyl ether
- CAS NO.：589-10-6
- Empirical Formula: C8H9BrO
- Molecular Weight: 201.06
- MDL number: MFCD00000234
- EINECS: 209-634-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:13:50
What is 2-Phenoxyethylbromide?
Chemical properties
White Solid
The Uses of 2-Phenoxyethylbromide
2-Phenoxyethyl bromide is used in the synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.
What are the applications of Application
2-Phenoxyethyl bromide can be used as a pharmaceutical intermediate for the synthesis of nafazodone and oxiperomide.
Preparation
2-Phenoxyethyl bromide is synthesized by the reaction of phenol and dibromoethane. Put phenol, dibromoethane and sodium hydroxide in a reaction pot and stir and mix, react at 110 °C for 6 hours, recover dibromoethane, the recovery amount is about 60%, wash with 5% sodium hydroxide solution and water, and divide Take the oil layer, distill under reduced pressure, and collect the fractions at 130-150°C (6.7kPa) to obtain (2-bromoethoxy)benzene.
Properties of 2-Phenoxyethylbromide
| Melting point: | 31-34 °C(lit.) |
| Boiling point: | 144 °C40 mm Hg(lit.) |
| Density | 1.45 |
| refractive index | 1.555-1.557 |
| Flash point: | 150 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Solubility in methanol is almost transparent. Soluble in chloroform and ethyl acetate. |
| form | Liquid After Melting |
| color | Clear colorless |
| Water Solubility | Insoluble in water. |
| BRN | 508290 |
| CAS DataBase Reference | 589-10-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, (2-bromoethoxy)-(589-10-6) |
| EPA Substance Registry System | Benzene, (2-bromoethoxy)- (589-10-6) |
Safety information for 2-Phenoxyethylbromide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2-Phenoxyethylbromide
New Products
Indole Methyl Resin tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Boc-His(Boc)-OH 2-CTC Resin 4-Chloro-7-tosy1-7Hpyrrolo[2,3-d]pyrimidine 5,7-Dibromo-1H-indole 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidamide 2,2-Dimethoxy-7-azaspiro[3.5]nonane hydrochloride 4-chloromethyl-5-methyl-1,3-dioxol-2-one (DMDO-Cl) R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDIIMIDAZOLE 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID 4-((2-hydroxyethyl)thio)benzoic acid 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE Methyl 6-methylnicotinate 3-Pyridineacrylic acid tert-Butyl carbazate TETRAHYDRO-2H-PYRAN-3-OL 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile 2,4-dihydroxybenzaldehyde 1,3-Diethyl-1,3-Diphenylurea Methyl 2-methylquinoline-6-carboxylateRelated products of tetrahydrofuran
![5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]aMino]propyl]-2-Methoxybenzenesulfonic Acid](https://img.chemicalbook.in/CAS/GIF/890708-67-5.gif)
![(-)-Bis[(S)-1-phenylethyl]amine](https://img.chemicalbook.in/CAS/GIF/56210-72-1.gif)
You may like
-
589-10-6 beta-Bromophenetole 98%View Details
589-10-6 -
β-Bromophenetole, 98% CAS 589-10-6View Details
589-10-6 -
2-Phenoxyethyl bromide CAS 589-10-6View Details
589-10-6 -
β-Bromophenetole CAS 589-10-6View Details
589-10-6 -
β-Bromophenetole CAS 589-10-6View Details
589-10-6 -
Pyridine 99.5% HPLC /UV SpectroscopyView Details
110-86-1 -
Dibutyl PhthalateView Details
84-74-2 -
Thiourea 99% ARView Details
62-56-6
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.