2-Phenoxyethylbromide
Synonym(s):2-Bromoethyl phenyl ether
- CAS NO.：589-10-6
- Empirical Formula: C8H9BrO
- Molecular Weight: 201.06
- MDL number: MFCD00000234
- EINECS: 209-634-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:38
What is 2-Phenoxyethylbromide?
Chemical properties
White Solid
The Uses of 2-Phenoxyethylbromide
2-Phenoxyethyl bromide is used in the synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.
What are the applications of Application
2-Phenoxyethyl bromide can be used as a pharmaceutical intermediate for the synthesis of nafazodone and oxiperomide.
Preparation
2-Phenoxyethyl bromide is synthesized by the reaction of phenol and dibromoethane. Put phenol, dibromoethane and sodium hydroxide in a reaction pot and stir and mix, react at 110 °C for 6 hours, recover dibromoethane, the recovery amount is about 60%, wash with 5% sodium hydroxide solution and water, and divide Take the oil layer, distill under reduced pressure, and collect the fractions at 130-150°C (6.7kPa) to obtain (2-bromoethoxy)benzene.
Properties of 2-Phenoxyethylbromide
| Melting point: | 31-34 °C(lit.) |
| Boiling point: | 144 °C40 mm Hg(lit.) |
| Density | 1.45 |
| refractive index | 1.555-1.557 |
| Flash point: | 150 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Solubility in methanol is almost transparent. Soluble in chloroform and ethyl acetate. |
| form | Liquid After Melting |
| color | Clear colorless |
| Water Solubility | Insoluble in water. |
| BRN | 508290 |
| CAS DataBase Reference | 589-10-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, (2-bromoethoxy)-(589-10-6) |
| EPA Substance Registry System | Benzene, (2-bromoethoxy)- (589-10-6) |
Safety information for 2-Phenoxyethylbromide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2-Phenoxyethylbromide
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