2-Phenoxyaniline
Synonym(s):2-Aminophenyl phenyl ether
- CAS NO.：2688-84-8
- Empirical Formula: C12H11NO
- Molecular Weight: 185.22
- MDL number: MFCD00035765
- EINECS: 220-254-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:30
What is 2-Phenoxyaniline?
Chemical properties
Whitetolightyellowcrystalpowde
The Uses of 2-Phenoxyaniline
2-Phenoxyaniline serves as an antiinflammatory agent that inhibits preferentially COX-2 over COX-1. It is used in the preparation of sodium primary amide complex, 4-methyl-2-(2-phenoxyphenyl)azo-phenol and 2-acetoaminodiphenyl ether. Further, it is used to form complexes with beta-cyclodextrin.
The Uses of 2-Phenoxyaniline
2-Phenoxyaniline may be used in the preparation of sodium primary amide complex, 2-PhOC6H4NHNa·NMe[(CH2)2NMe2]2. It was used in the preparation of 2-acetoaminodiphenyl ether. It may be used in the preparation of 4-methyl-2-(2-phenoxyphenyl)azo-phenol.
General Description
2-Phenoxyaniline forms crystalline 2:1 (host-to-guest) inclusion complexes with β-cyclodextrin.
Safety Profile
Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.
Properties of 2-Phenoxyaniline
| Melting point: | 47-49 °C(lit.) |
| Boiling point: | 170 °C18 mm Hg(lit.) |
| Density | 1.0936 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Slightly soluble in chloroform and methanol. |
| form | Crystalline Powder or Flakes |
| pka | 3.78±0.10(Predicted) |
| color | Brown to gray |
| BRN | 777766 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 2688-84-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Aminodiphenyl ether(2688-84-8) |
| EPA Substance Registry System | o-Phenoxyaniline (2688-84-8) |
Safety information for 2-Phenoxyaniline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Phenoxyaniline
2-Phenoxyaniline manufacturer
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